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Topic: Acid Workup  (Read 22236 times)

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Offline Messi

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Acid Workup
« on: November 06, 2012, 08:31:15 PM »
What is meant when someone says an acid workup?

I reacted my compound with TFA, would that be considered an acid workup?  ???

Offline discodermolide

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Re: Acid Workup
« Reply #1 on: November 06, 2012, 10:51:19 PM »
An acid work-up is where acid, usually a mineral acid or perhaps acetic acid depending really upon how acid stable your compound is, is used to remove basic components of a reaction mixture, or to re-protonate a basic compound.
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Offline Messi

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Re: Acid Workup
« Reply #2 on: November 07, 2012, 06:17:36 PM »
Ok, great. Is this done at the end of the reaction, at the extraction step?

Offline discodermolide

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Re: Acid Workup
« Reply #3 on: November 07, 2012, 10:15:23 PM »
Not necessarily it can mean adding acid to the reaction to quench a reactive intermediate.
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