January 10, 2025, 01:50:34 PM
Forum Rules: Read This Before Posting


« previous next »
Pages: 1 [2]   Go Down

Topic: Help with a synthetic problem  (Read 7288 times)

0 Members and 1 Guest are viewing this topic.

Offline zuriel

  • Full Member
  • ****
  • Posts: 107
  • Mole Snacks: +2/-1
Re: Help with a synthetic problem
« Reply #15 on: November 23, 2012, 04:48:33 AM »
That would be great, zhangcarlin. Thanks.

I have the mechanism fairly well set at this stage myself too.

I'm still confused about the stereochemistry though. Is there anyway the stereochemistry might flip from the (R) form to the (S) form in structure A during the nucleophilic attack on the following structure:

Logged

Offline discodermolide

  • Chemist
  • Sr. Member
  • *
  • Posts: 5038
  • Mole Snacks: +405/-70
  • Gender: Male
    • My research history
Re: Help with a synthetic problem
« Reply #16 on: November 23, 2012, 04:51:59 AM »
The stereochemistry of the hydroxymethyl pyrrolidine is retained.
Logged
Development Chemists do it on Scale, Research Chemists just do it!
My Research History

Offline zuriel

  • Full Member
  • ****
  • Posts: 107
  • Mole Snacks: +2/-1
Re: Help with a synthetic problem
« Reply #17 on: November 23, 2012, 01:46:01 PM »
Thanks to everyone for discussing this synthesis with me. Huge thanks to you, discodermolide - your knowledge knows no bounds!!!  :)

If anyone would like me to post the synthetic route to AVANFIL (for interest's sake) which I managed to pull together, please let me know and I will do that.
Logged

Offline zhangcarlin

  • Regular Member
  • ***
  • Posts: 19
  • Mole Snacks: +0/-0
Re: Help with a synthetic problem
« Reply #18 on: November 24, 2012, 08:48:46 PM »
Sorry guys, I am at home and I do not have access to Reaxys now. So I must draw the route by myself.
Logged
Pages: 1 [2]   Go Up
« previous next »
Sponsored Links