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Topic: Methylmagnesium bromide  (Read 1413 times)

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Offline AlphaScent

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Methylmagnesium bromide
« on: January 22, 2013, 05:09:56 PM »
Does a methylation of a tosylate using methylmagnesium bromide need to be at -78 of 0 deg C ?  My  boss is out of town and have been thinking about the reaction.  I use butyl lithium at -78 when using it as a base and a nucleophile.  But what about methyl grignard? 
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Offline AlphaScent

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Re: Methylmagnesium bromide
« Reply #1 on: January 22, 2013, 05:14:28 PM »
This reaction calls for CuI.  So I have thought about it and realize that making the grignard (If I was) could be done at r.t.  But the addition of the grignard needs to be done at -78.  Thanks, but I thought a few min and realized my answer. 
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