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Topic: Protein Synthesis/Cleavage from solid phase resin  (Read 1634 times)

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Offline grint

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Protein Synthesis/Cleavage from solid phase resin
« on: January 30, 2013, 03:50:41 PM »
Question and attempt at part of an answer:
http://imgur.com/i6lHamJ,bE9l5hk#0

The Fmoc/Boc part of the question I can probably figure out later but mostly I'm having trouble with the mechanism for the amide linked resin and don't know if the first mechanism is correct/close to correct

Any help would be nice, thanks.
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Offline mamid

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Re: Protein Synthesis/Cleavage from solid phase resin
« Reply #1 on: February 01, 2013, 06:32:48 AM »
Looks OK. The other 2 Ph rings are also involved in the resonance, thus stabilizing the cation even further.
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