Topic: Will the hydroxyl group of a phenol be affected by H2 and a metal catalyst? (Read 1750 times)

limonade · « **on:** August 22, 2013, 02:52:41 PM »

I'm trying to reduce a cyano group to an amino group but I have a phenol on the same ring. Will using H2/Metal catalyst affect the phenol hydroxyl group adversely? How about Fe/HCl followed by sodium hydroxide?

Lithium aluminum hydride?

discodermolide · « **Reply #1 on:** August 22, 2013, 03:35:18 PM »

You should be OK. The best catalyst is Raney nickel in ethanol. You need to add ammonia gas to prevent the formation of secondary amines. You do this at normal temp. and pressure. everything else should be ok.

Topic: Will the hydroxyl group of a phenol be affected by H2 and a metal catalyst? (Read 1750 times)

limonade

Will the hydroxyl group of a phenol be affected by H2 and a metal catalyst?

discodermolide

Re: Will the hydroxyl group of a phenol be affected by H2 and a metal catalyst?

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