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Topic: Horner-Wadsworth-Emmons Reaction  (Read 1919 times)

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Offline missUK11

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Horner-Wadsworth-Emmons Reaction
« on: February 17, 2014, 03:53:18 PM »
Does the Horner Wadsworth Emmons reaction work with formaldehyde ??
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Offline AlphaScent

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Re: Horner-Wadsworth-Emmons Reaction
« Reply #1 on: February 17, 2014, 04:06:40 PM »
This seems silly to me in practice.  Just buy Ethyl crotonate.  But in theory I am sure it would.  May have to use excess phosphonate.
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Offline PhDoc

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Re: Horner-Wadsworth-Emmons Reaction
« Reply #2 on: February 17, 2014, 05:59:16 PM »
MissUK, it's important to realize that Horner-Emmons reagents (stabilized ylides) are used to introduce (E) stereochemistry in carbonyl compounds. There would be no logical synthetic utility for using formaldehyde.
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