January 07, 2025, 02:35:04 AM
Forum Rules: Read This Before Posting


« previous next »
Pages: [1]   Go Down

Topic: Boron Trifluoride Etherate  (Read 2151 times)

0 Members and 1 Guest are viewing this topic.

Offline AlphaScent

  • Full Member
  • ****
  • Posts: 644
  • Mole Snacks: +24/-7
  • Gender: Male
Boron Trifluoride Etherate
« on: January 03, 2015, 10:03:04 PM »
Does anyone have a good reference about this reagent and how it helps with epoxide opening?

A good read about the nature of the compound, if you will?
Logged
If you're not part of the solution, then you're part of the precipitate

Offline discodermolide

  • Chemist
  • Sr. Member
  • *
  • Posts: 5038
  • Mole Snacks: +405/-70
  • Gender: Male
    • My research history
Re: Boron Trifluoride Etherate
« Reply #1 on: January 04, 2015, 12:27:23 AM »
It coordinates to the oxygen atom hence causing the carbons to be prone to nucleophillic attack.
The reagent is very corrosive. Fumes in moist air, and is flammable. Not a particularly nice compound
Logged
Development Chemists do it on Scale, Research Chemists just do it!
My Research History

Offline AlphaScent

  • Full Member
  • ****
  • Posts: 644
  • Mole Snacks: +24/-7
  • Gender: Male
Re: Boron Trifluoride Etherate
« Reply #2 on: January 04, 2015, 02:01:07 PM »
Thanks Disco!!

I understand that it is a commonly used Lewis acid.  I was just looking for a good read about when it should be used and all that.  From what you said it seems you really do not want to and should find another Lewis acid when possible.

Logged
If you're not part of the solution, then you're part of the precipitate

Offline discodermolide

  • Chemist
  • Sr. Member
  • *
  • Posts: 5038
  • Mole Snacks: +405/-70
  • Gender: Male
    • My research history
Re: Boron Trifluoride Etherate
« Reply #3 on: January 04, 2015, 02:26:39 PM »
It is a great LA when you are dealing with oxygen containing systems, like epoxides, enolates and the like. It can be easily handled on scale. Buffered work ups to avoid it becoming too acidic. Avoid reducing conditions.
Logged
Development Chemists do it on Scale, Research Chemists just do it!
My Research History
Pages: [1]   Go Up
« previous next »
Sponsored Links