[Nescafe]

Hi,

I was just wondering why in Medicinal Chemistry pyridine group is considered "not drug-like". Is it because it can oxidize?

Someone mentioned it in a group meeting and everyone seemed to agree but I can not find any support as to why pyridine functionality would not be ideal on a drug

Thanks,

Nescafe.

[discodermolide]

I don't know where this came from, but I don't agree. There are plenty of drugs containing pyridine rings. Just look at this publication: dx.doi.org/10.1021/jm501237k , which discuses kinase inhibitors.

[phth]

It is also a catalyst.  It has been proven that nicotine causes cancer when administered alone in animal models.