[bobmc]

Hi! i am preparing cisplatin and i used procedure based on DHARA synthesis, one-pot reaction, it seems that the yield is only about 35 % in my case, i am afraid it can be a problem not to use good amounts of chemicals.If ayone prepare cisplatin and have higher yield - are this proportions OK? e.g. for 200 mg of K2PtCl4 use 320 mg of KI , then i use that amount of ammonia till all brown stuff disappear, then 640 mg of AgNO3 , and at the end 70 mg og KCl.
Thanks!!

[kriggy]

why dont you just recalculate the amounts of reagents in the DHARA article into moles and then compare with the amounts you used (in moles)

[bobmc]

Because in some newer publication they used a little bit different amounts and called it "improved" method, but using this it was still about 35 % of yield, i asked someone and they said something even different, so i dont know how exactly should it be to obtain the best result...

[Arkcon]

So how different are the amounts?  And again, when converted to moles, are these new amounts significantly different?  Also, what yields are reported in the publications?