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Topic: EDC (carbodiimide) Stability  (Read 4971 times)

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Offline UOstudent1016

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EDC (carbodiimide) Stability
« on: December 10, 2015, 07:01:22 PM »
Does anyone out there know: if I leave my Container of wed out and allow it to room temp, and then weight out what I need, will the EDC degrade significantly as it warms up to RT?
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Offline Yggdrasil

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Re: EDC (carbodiimide) Stability
« Reply #1 on: December 10, 2015, 07:41:51 PM »
Given that EDC is typically shipped at room temperature it is probably fine.  Letting the EDC warm to room temp before opening is important to avoid condensation of moisture from the air inside the container, which would lead to degradation of the EDC.
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Offline eskil

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Re: EDC (carbodiimide) Stability
« Reply #2 on: December 23, 2015, 10:18:44 AM »
Why is this reagent commercially available as free base as well as HCl salt? I have seen peptide and peptide like couplings being done using both. In what circumstance should one choose one over the other?
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