December 27, 2024, 03:05:02 AM
Forum Rules: Read This Before Posting


« previous next »
Pages: [1]   Go Down

Topic: Making paracetamol  (Read 2123 times)

0 Members and 1 Guest are viewing this topic.

Offline mystreet123

  • Regular Member
  • ***
  • Posts: 24
  • Mole Snacks: +0/-0
Making paracetamol
« on: May 08, 2016, 03:45:20 AM »
Why ethanoic anhydride did not react with -OH group in 4-aminophenol to form ester?
Logged

Offline OCSaviour

  • Regular Member
  • ***
  • Posts: 26
  • Mole Snacks: +2/-3
Re: Making paracetamol
« Reply #1 on: May 08, 2016, 07:10:07 AM »
Because NH2 acts as a better nucleophilic site than OH, hence the NH2 attacks the electrophilic carbonyl group.
« Last Edit: May 08, 2016, 07:23:53 AM by OCSaviour »
Logged

Offline discodermolide

  • Chemist
  • Sr. Member
  • *
  • Posts: 5038
  • Mole Snacks: +405/-70
  • Gender: Male
    • My research history
Re: Making paracetamol
« Reply #2 on: May 08, 2016, 07:19:20 AM »
Watch your terminology, nucleophiles attack electrophiles, especially when you are talking about a carbonyl group.
Logged
Development Chemists do it on Scale, Research Chemists just do it!
My Research History
Pages: [1]   Go Up
« previous next »
Sponsored Links