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Topic: Ester Hydrolysis with TFA  (Read 4433 times)

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Offline fransiska.k

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Ester Hydrolysis with TFA
« on: May 20, 2016, 06:10:12 AM »
Dear all,

Anyone know the mechanism how tert-butyl ester can be hydrolysis by using TFA? What happened to the CF3COO- after the reaction? Anyway, I have pyrazole in the other side chain, is this will affected (protonated) by TFA? If it can be protonated and make salt with CF3COO-, how can I break this salt and get my target compound?

Additional info : my product after hydrolisis is water soluble

Thank you for helping me..

- Siska -
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Offline Babcock_Hall

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Re: Ester Hydrolysis with TFA
« Reply #1 on: May 20, 2016, 02:09:01 PM »
Siska,

Welcome to the forum.  Please read the Forum Rules.  You must show your attempt before we can help you.
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Offline Babcock_Hall

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Re: Ester Hydrolysis with TFA
« Reply #2 on: June 06, 2016, 04:45:24 PM »
Hint:  I would think in terms of an elimination reaction.
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