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Topic: Boc group deprotection in PBr3  (Read 4611 times)

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devesh

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Boc group deprotection in PBr3
« on: May 21, 2006, 04:45:57 PM »
I have reacted one of my substrate having Boc with PBr3 and ended up in the cleavage. Is Boc labile in PBr3? In that case can you recommend me the suitable protecting agent for this.
Thankx in anticipation.
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Offline Dan

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Re: Boc group deprotection in PBr3
« Reply #1 on: May 21, 2006, 05:27:40 PM »
Can you give information about the substrate or the transformation you are trying to achieve? Is it possible that you are generating HBr in-situ, that would make the Boc drop off?

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Offline movies

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Re: Boc group deprotection in PBr3
« Reply #2 on: May 22, 2006, 04:05:51 PM »
If your in love with carbamates, maybe try a CBz group instead.
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