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Topic: Dissolving dutasteride to make 5% solution....please advise  (Read 2178 times)

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Offline PacNorWester

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Dissolving dutasteride to make 5% solution....please advise
« on: October 31, 2016, 12:48:46 AM »
Can anyone advise best way to do this? I used 2.5 grams in 35 ml of ethanol/200 proof and it did not dissolve much. I added more etoh to the 50ml  (vs using prop glycol) and its still so cloudy. Is this a supersaturated solution? I have used 1 gram before with similar volume of etoh with better results.
What is this saying about the solubility of dutasteride? Is it impossible for me to make a 5%?  Maybe its not real? What do i do?
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Offline Hunter2

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Re: Dissolving dutasteride to make 5% solution....please advise
« Reply #1 on: October 31, 2016, 03:37:10 AM »
In Ethanol its only 50 mM solubilty. Better is to use DMSO.
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Offline Dan

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Re: Dissolving dutasteride to make 5% solution....please advise
« Reply #2 on: October 31, 2016, 06:50:05 AM »
According to this source, dutasteride is soluble in:

ethanol (44 mg/ml)
methanol (64 mg/ml)
polyethylene glycol 400 (3 mg/ml)
DMSO (62 mg/ml)
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