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Topic: Synthesis of amides with EDC and HOBt  (Read 9931 times)

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Offline DavidW

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Synthesis of amides with EDC and HOBt
« on: June 12, 2006, 10:15:00 AM »

I'm planning to run some coupling reactions with carboxylic acid and amine, using EDC and HOBt, to make amides.  I was wondering if the reaction would still work if I were to use carboxylic acid salt, instead of the neutral carboxylic acid? 
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Offline HP

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Re: Synthesis of amides with EDC and HOBt
« Reply #1 on: June 13, 2006, 01:29:47 PM »
Nope the activation mechanism with carbodiimides requier COOH and COO:-Na+ cant effectively activate it.


« Last Edit: June 13, 2006, 02:25:03 PM by Borek »
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