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Topic: Removal of Bn proecting group  (Read 1793 times)

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Offline Bakterien

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Removal of Bn proecting group
« on: November 16, 2017, 03:38:32 PM »
I have a molecule with the group N-O-Bn. I want to remove the benzyl protecting group so I get N-hydroxy as my product. Any suggestions ?

Pd/C hydrogen: Do I need heat / pressure ?
LiAlH4 ?
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Offline rolnor

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Re: Removal of Bn proecting group
« Reply #1 on: November 16, 2017, 10:04:21 PM »
I think you will reduce the hydroxylamine to amine if you use these methods, maybe trimethylsilyl iodide could work if the rest of the molecule can withstand it.
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