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For carbamate to ester
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Topic: For carbamate to ester (Read 3312 times)
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faust
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For carbamate to ester
«
on:
June 21, 2006, 05:26:19 AM »
Hello.
Does somebody know the mecanism of this kind of reaction .
R*-NHCOOMe --H2SO4/MeOH --> R*-COOMe...
I can't find out a mecanism.
Thank you again for your precious help.
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AWK
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Re: For carbamate to ester
«
Reply #1 on:
June 21, 2006, 05:55:23 AM »
Reversed route is known as Hoffman amide rearrangement
see:
http://www.orgsyn.org/orgsyn/prep.asp?prep=v78p0234
http://curie.umd.umich.edu/decamp/c226/Hofmann%20rearrangement.pdf
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Last Edit: June 21, 2006, 06:06:42 AM by AWK
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For carbamate to ester