[organicstudent]

The question is asking how to convert the nitro compound into the product explaining the order of events with regard to reduction steps.

I have tried researching cyclisation reactions involving the reduction of NO₂ but have found little to nothing. I think that the reaction has something to do with protection groups; protection of the carbonyl.

Thank you!

[crawlingmcedge]

I would guess first reduce to the aniline first. I suppose then use SOCl2 to change to acid chloride which would give self cyclization.

Remove the carbonyl using clemmenson or wolf kishhner

[zsinger7]

If you had "researched everything," you would know the answer!  Try the Mozingo reduction (OUTSIDE!!!!!) if you have a sensitive substrate.  Use Wolff-Kishner with acid sensitive, Clemmensen with base sensitive, or Mozingo as a last resort (trust me, Me2S is HORRIBLE STUFF!).  And as stated above, nitro must be reduced (Use tin/HCl then freebase it).

        -Zack

[Arkcon]

OK, thanks to everyone for playing.  That was great.  You're beautiful, all of ya's.  :Golf Clap:

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