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Topic: Converting ester to amide in one pot  (Read 13609 times)

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Offline wildfyr

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Re: Converting ester to amide in one pot
« Reply #30 on: December 10, 2018, 04:42:48 PM »
You gotta keep that thing pretty cold or else it will undergo spontaneous Curtius rearrangement
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Offline kriggy

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Re: Converting ester to amide in one pot
« Reply #31 on: December 11, 2018, 03:57:50 AM »
That looks pretty cool.
So, the acid azide is just heated with amine to get the amide?

ah I see, with heating I get the courtious rearangement, not that this wouldnt be interesting as well, to get some urea derivatives there
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Offline rolnor

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Re: Converting ester to amide in one pot
« Reply #32 on: December 11, 2018, 05:59:30 AM »
If you have some DMAP as catalyst you probably dont need heating.
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Offline kriggy

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Re: Converting ester to amide in one pot
« Reply #33 on: January 07, 2019, 02:45:24 AM »
Do you have some literature examples of the azide :rarrow: amide tranformation?
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Offline rolnor

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Re: Converting ester to amide in one pot
« Reply #34 on: January 07, 2019, 05:19:46 AM »
No, sorry. But this is an old reaction, also used i peptide synthesis, if you search on Scifinder etc. you will get hits.
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