[seant]

Recently i got imprisoned into a psychiatric prison where was treated with a neuroleptic drug called trifluoperazine hydrochloride. The drug in powder form was given by mouth; it got onto my teeth where was dissolved in saliva and water and then swallowed. I saw that my gums receded, are all bleeding and my teeth are hurting. I have tooth pain after many months. I read that the substance itself is an irritant; i wonder, does it get into reaction with tooth enamel, calcium?

[rolnor]

These symptoms is surprising for a drug that has been used in clinic, are you sure that there is no chanse that you are psycotic and maybe are imagining these adverse effects? This is common in treating psykotic patients that they have strong negative experiences with the medication. There is nothing wrong with this and I am not acusing you but ask this to make you aware of this risc. As a matter if fact I have used this drug myself in powder-form and I did not have any if these symptoms you describe. I used it to treat anxiety under a short period of time. This is a low-dose neuroleptica and usually very small amount is needed to get clinical response.  Take care.

[seant]

They use it here in big amounts, 15 -80 mg or so per day. What dose tablets are you using?
1 mg of course i would not feel.

[rolnor]

I used 1mg so it may be different with large amounts. I must say this is a very old drug, there is better medication available today, its very sad you get these severe adverse effects. Olanzapine is better, less risc of extrapyramidal effects.

[seant]

I know, no person in their normal mind would take this substance, but it is given by force in a special prison in Russia. They also use haloperidol and aminazin; they cause swellings of muscles, permanent nervous system damage, ect. But my question is about chemistry, whether this substance reacts with enamel of teeth or not? Could set up a test if you have access to it; what is it like - acid or what?

[rolnor]

No, its a almost neutral hydrochloride and the molecule iself is not reactiv.It can give dry mouth.


https://en.m.wikipedia.org/wiki/Trifluoperazine

[seant]

The substance is burning, just like another derivative of phenotiazine - chlorpromazine, which leaves a *Ignore me, I am impatient* at the point on injection, sometimes causes necrosis of tissue. In my case it irritated gums and they started to disconnect from teeth. But i dont know anything about organic chemistry, and whether such complex substances as this one and tooth enamel can interact with each other; although it cripples the body in many other ways.

[rolnor]

It sounds as if they are giving you something else then they are telling you, it sounds terrible. These substances are not agressive in in way, you should not have this type of reaction from teeth and gum.

[Enthalpy]

I doubt about the drug having nearly neutral pH. The question is about the hydrochloride, and it seems pretty acidic to me:
https://www.drugfuture.com/mt/trifluoperazine-hydrochloride.pdf
"A 10% solution in water has a pH of 1.6 to 2.5."

This is about as acidic as ascorbic acid, and if you chew Guronsan (contains 40% ascorbic acid) instead of dissolving it in water, you damage your teeth.

Having the drug in powder form in long contact with the teeth would be worse than chewing Guronsan for a shorter time.

[rolnor]

That seems correct Enthalpy. In this case it must be a dihydrochloride? It containes a piperazine ring.

[OrganicH2O]

If given over a long period of time, the acidity could be an issue. It could also be a combination of dry mouth caused by the drug, and poor dental hygiene over a long period of time. Dry mouth makes dental problems build up over time more severely, and you probably weren't able to brush/floss regularly for some period of time if you were incarcerated like that. Good brushing/flossing might help reverse some of the issues you are having. An electric tooth brush is especially helpful. Don't over-do it too much, because excessive brushing and flossing can also be bad for your teeth. Disclaimer: I'm not a dentist, this is just from personal experience and things I've read.

[rolnor]

But he has pain in teeth?