Topic: Decarboxylation of a solution of Orotic acid? (Read 1193 times)

Jeffrey777 · « **on:** October 17, 2019, 12:10:53 PM »

What would be the best method for decarboxylation of orotic acid? Can sodium hydroxide be used for this purpose?

hollytara · « **Reply #1 on:** October 17, 2019, 12:22:19 PM »

Do you have access to the enzyme?

See Biochemistry. 2009 Sep 15; 48(36): 8738–8745.
doi: 10.1021/bi901085m

Jeffrey777 · « **Reply #2 on:** October 17, 2019, 01:54:11 PM »

I know there is an enzyme decarboxylase, but this is meant to be an experiment in prebiotic chemistry, showing the formation of uracil when there were no enzymes.

Jeffrey777 · « **Reply #3 on:** October 17, 2019, 01:55:39 PM »

Thanks for the quick reply, btw!

AWK · « **Reply #4 on:** October 17, 2019, 03:58:33 PM »

https://pubs.acs.org/doi/abs/10.1021/jo01327a020

Jeffrey777 · « **Reply #5 on:** October 17, 2019, 04:08:35 PM »

Thank you very much for that! Actually I did come across that article, and so that was always a possible option. I just wanted to see if anybody here had any other ideas. Thanks very much!

Topic: Decarboxylation of a solution of Orotic acid? (Read 1193 times)

Jeffrey777

Decarboxylation of a solution of Orotic acid?

hollytara

Re: Decarboxylation of a solution of Orotic acid?

Jeffrey777

Re: Decarboxylation of a solution of Orotic acid?

Jeffrey777

Re: Decarboxylation of a solution of Orotic acid?

AWK

Re: Decarboxylation of a solution of Orotic acid?

Jeffrey777

Re: Decarboxylation of a solution of Orotic acid?

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