Topic: Is this mechanism correct and if it is would it give a good yield? (Read 1325 times)

JoeyBob · « **on:** February 28, 2020, 08:53:56 PM »

See below. The product is the racemic compound.

hollytara · « **Reply #1 on:** February 28, 2020, 10:33:42 PM »

It isn't a mechanism, it is a proposed synthesis or synthetic scheme.

hollytara · « **Reply #2 on:** February 28, 2020, 10:38:45 PM »

Most of the steps are good - but the last two aren't the best. The imine from the acetophenone and methanamine can be reduced in situ using sodium cyanoborohydride. Isolating the imine is not always that easy - it can easily hydrolyze.

JoeyBob · « **Reply #3 on:** February 29, 2020, 12:33:59 AM »

Quote from: hollytara on February 28, 2020, 10:38:45 PM

Most of the steps are good - but the last two aren't the best. The imine from the acetophenone and methanamine can be reduced in situ using sodium cyanoborohydride. Isolating the imine is not always that easy - it can easily hydrolyze.

Thanks. Toluene is kinda expensive. Is phenylacetone easy to get?

rolnor · « **Reply #4 on:** February 29, 2020, 04:38:15 AM »

Synthesis of amphetamine or other drugs have no place here.

Borek · « **Reply #5 on:** February 29, 2020, 07:14:04 AM »

Please read the forum rules. We have no problems discussing mechanisms, but not synthesis schemes.

Topic locked.

Topic: Is this mechanism correct and if it is would it give a good yield? (Read 1325 times)

JoeyBob

Is this mechanism correct and if it is would it give a good yield?

hollytara

Re: Is this mechanism correct and if it is would it give a good yield?

hollytara

Re: Is this mechanism correct and if it is would it give a good yield?

JoeyBob

Re: Is this mechanism correct and if it is would it give a good yield?

rolnor

Re: Is this mechanism correct and if it is would it give a good yield?

Borek

Re: Is this mechanism correct and if it is would it give a good yield?

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