December 26, 2024, 03:26:06 AM
Forum Rules: Read This Before Posting


Topic: conversion of chloropropanol to mercaptopropanol  (Read 3947 times)

0 Members and 1 Guest are viewing this topic.

Offline awais

  • Regular Member
  • ***
  • Posts: 21
  • Mole Snacks: +0/-1
  • Gender: Male
  • Electron
conversion of chloropropanol to mercaptopropanol
« on: September 15, 2006, 03:24:04 AM »
I have 2 questions:

1. I have to convert 1,3-dichloro-2-propanol to 1,3-dimercapto-2-propanol, using some safer method which should not effect the OH group.

2. How to convert the COOH group to ester. compound to be covert is 1,3-dibromo-2-carboxylic acid.

This is really nice forum where i found lot of solutions n i thank all of.
Awais Anwar
Bioorganic Chemistry
University of Saarland, Germany
+49 176 26260734

Offline AWK

  • Retired Staff
  • Sr. Member
  • *
  • Posts: 7976
  • Mole Snacks: +555/-93
  • Gender: Male
Re: conversion of chloropropanol to mercaptopropanol
« Reply #1 on: September 15, 2006, 05:30:44 AM »
1. I think a formal double exchange reaction with KHS or NaHS will work
2. Use PBr3 followed by an alcohol.
AWK

Offline awais

  • Regular Member
  • ***
  • Posts: 21
  • Mole Snacks: +0/-1
  • Gender: Male
  • Electron
Re: conversion of chloropropanol to mercaptopropanol
« Reply #2 on: September 16, 2006, 06:45:10 AM »
Thanks, do u have any procedure, i mean i m not a good chemist
Awais Anwar
Bioorganic Chemistry
University of Saarland, Germany
+49 176 26260734

Offline AWK

  • Retired Staff
  • Sr. Member
  • *
  • Posts: 7976
  • Mole Snacks: +555/-93
  • Gender: Male
Re: conversion of chloropropanol to mercaptopropanol
« Reply #3 on: September 18, 2006, 03:50:52 AM »
Some excess of reagents are needed. Use anhydrous conditions in the reaction with PBr3.
AWK

Sponsored Links