[whitecoatblackhat]

Fellow Chemists,

I'm trying to dissolve pure Adenosine powder, not AMP, ADP or ATP.

However, I can't find a vehicle that allows me to dissolve higher concentrations of Adenosine.

I don't want to introduce heat into the equation because I need the adenosine to stay dissolved at room temperature.

Heating up the vehicle is only a temporary solution.

The most distilled water can dissolve is 300-350mg of adenosine anhydrous per 100 ml of water.

Ethanol doesn't work.

Propylene Glycol and peg 40 hydrogenated solubility aren't efficient solubilizers as well.

And I don't want to use DMSO.

Any other suggestions?

All will be highly appreciated!

Thank you!

[AWK]

This is the solubility of adenosine at ~RT.

[rolnor]

Methanol?

[whitecoatblackhat]

This is the solubility of adenosine at ~RT.

Sorry, what do you mean by that?

That's the solubility of adenosine at room temperature, in water?

Isn't that what I just wrote above?

Not sure, what you meant by this comment, but thanks for taking the time to reply!

[whitecoatblackhat]

Methanol?

Yeah, methanol would be a great vehicle but I'm going to apply the Adenosine solution to my research subject's skin.

Hence, methanol (similar to DMSO) is definitely not suitable.

Thanks for the input!

[AWK]

More adenosine will not dissolve in the water. In alcohol, adenosine dissolves even less.

[whitecoatblackhat]

More adenosine will not dissolve in the water. In alcohol, adenosine dissolves even less.

Thanks for replying, but you're definitely not carefully reading my question.

You're literally repeating what I just said in my post.

Please, read it again.

My question was not how to dissolve more adenosine in water.

My question was what is a better vehicle for adenosine than water.

Thanks

[AWK]

Rather, you don't understand the essence of solubility.
Polar compounds (and such is adenosine) dissolve better in polar solvents (and such is water).
In Pharmacy (rather topically) DMSO is sometimes used (in which adenosine dissolves better).
And those are probably all options.

[AWK]

The solubility of adenosine in 1M HCl is about 5 g/100 ml.

[whitecoatblackhat]

Rather, you don't understand the essence of solubility.
Polar compounds (and such is adenosine) dissolve better in polar solvents (and such is water).
In Pharmacy (rather topically) DMSO is sometimes used (in which adenosine dissolves better).
And those are probably all options.

Thanks for the reply. I'm very aware of the basic principles of solubility.

I honestly don't understand why we're even discussing this.

I clearly stated that I'm looking for other vehicles that can possibly solubilize pure anhydrous adenosine.

@rolnor Got it immediately and proposed a potential solvent, i.e. methanol (which is exactly what I asked for).

But you simply keep repeating what I said in my original post.

Also, there are many proprietary solvents like TrichoSol, which clearly you aren't aware of because you think that DMSO is the end all be all.

TrichoSol doesn't work in my case and that's why I'm posting a question here.

To gather ideas for other such solvents, be it proprietary or not.

Most importantly, there's clinical data in which adenosine is dissolved at 0.75% and is applied topically on the scalp for the treatment of androgenic alopecia, however, the methods of preparation aren't specified.

They surely aren't applying DMSO or methanol to people's scalps.

This means that there are skin-safe solvents out there that can dissolve adenosine at a higher than 0.30% concentration (which is the highest concentration in water).

Thanks a lot for taking the time to reply, though. I genuinely appreciate your input!

P.S. I did contact the authors of the adenosine 0.75% studies and got no replies.

[rolnor]

You dont have many options, very few solvents are possible to apply topical. Maybe glycerol?

[whitecoatblackhat]

You dont have many options, very few solvents are possible to apply topical. Maybe glycerol?

Interesting. Thanks for the suggestion!

I can't find any data on the solubility of adenosine in glycerol but I might buy some and try it myself.

[AWK]

There are clever solutions to this problem (stabilized supersaturated solutions - up to 2%) but they are outside the scope of this Forum. Search in patents.

[rolnor]

So its hair-loss we are talking about?
https://rarediseases.info.nih.gov/diseases/9269/androgenetic-alopecia

I really wonder if adenosine is better than Minoxidil etc. This is a well studied problem, I think you will have more luck with the standard treatment even though it is expensive.

[whitecoatblackhat]

There are clever solutions to this problem (stabilized supersaturated solutions - up to 2%) but they are outside the scope of this Forum. Search in patents.

This is the info I was looking for! Great stuff! Thanks!

Do you mean that you know of certain ways to create a supersaturated solution that can dissolve adenosine up to 2%?

Thanks!