[jeffmoonchop]

Hello!

If you had three solutions and by antisolvent addition you brought the first solution to supersaturation past the metastable limit, and the other two were taken to a supersaturation of 2x and 3x the first solution, would the crystallinity (vs amorphous) of the final products be same, despite different nucleation rate, or would an increase in supersaturation encourage crystallinity, or vice versa?

I know the final particle size would be smaller as supersaturation increases, but my question is based on the likelihood of forming a crystal vs an amorphous product. I spent my PhD with my supervisor telling me that to form hard to crystalize material, you need to ramp up supersaturation. Just wanted to get any second opinions.

Thanks