December 21, 2024, 12:18:06 PM
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Topic: Internal or external attack in grignard reagent  (Read 485 times)

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Offline Hello299

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Internal or external attack in grignard reagent
« on: December 06, 2024, 10:25:45 PM »
I can't understand when there will be an internal attack and when it will be an outside attack.

Offline Hunter2

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Re: Internal or external attack in grignard reagent
« Reply #1 on: December 07, 2024, 12:46:02 PM »
The first reaction is Addition of grignard at acid anhydride a carbonyl compound. It reaction like described.
The second one is the reaction of grignard with  a alcohol. The alcoholat with Magnesium bromide will reaction with the chlorine ans close the Ring to THF.

Offline Borek

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Re: Internal or external attack in grignard reagent
« Reply #2 on: December 08, 2024, 06:04:16 PM »
Internal, or intramolecular?
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