[lutesium]

Dear Sir Ma'am

How can I attach a picture in here?


How can this conversion be made? By the grignard addition of BrMgCN to the ketone group? (How can a ketone's oxygen be turned into an -OH and -CN bond?

[Borek]

How can I attach a picture in here?

Click on Additional Options... below edit field.

[sjb]

Consider the polarity of the carbonyl bond, and that of the cyanide ion, together with the Lewis structure for the latter. Does making a grignard of the cyanide ion make formal sense?

[lutesium]

Where is that edit field?

For sjb:
I'm just asking how they've made this reaction. Does a ketone and a cyanide ion upon making Grignard give a hydroxyl and a nitrile?


Lutesium...

[Borek]

Where is that edit field?

Place where you type your message. You know, like a white box right in the middle of your screen

[lutesium]

How can this conversion be made?


Lutesium...

[lutesium]

I suppose to make a Grignard Reaction between the Piperidone and Br-Mg-CN. Is this way suitable for the reaction scheme?


Lutesium...

[lutesium]

Is there anyone who can help me?


Lutesium...

[sjb]

You don't need to make the Grignard, as cyanide is already negatively charged. However, the formation may be reversible, so be careful.