[Bmaster]

A problem is very much puzzling me any thoughts/help on how to answer this is appreciated

 Hemoglobin plays a part in a series of equilibria involving protonation-deprotonation and oygenation-deoxygenation. THe overall reaction is approximately as follows: HbH^+ (aq) +02(aq)----> Hbo2(aq) + H^+(aq) (Where HbH^+ stands for hemoglobin, and Hb02 stands for oxyhemoglobin)

A) The concentration of 02 is higher in the lungs and lower in the tissues. What effect does a [02] have on the position of this equilibrium?
B) The normal pH of blood is 7.4. What is the [H^+] in normal blood? Is it acidic, basic , or neutral?
C) If the blood pH is lowered by the presence of large amounts of acidic metabolism products, a condition known as acidosis results, What effect does lowering the blood pH have on the ability of hemoglobin to transport 02?

Thanks in advance

[wilson]

For Q1 and Q3, Use Le Chatelier's Principle.

For Q2, consider the definition of pH. Consider what is the neutral pH at 25C.

[cliverlong]

Isn't an acid-base buffer argument usually used to explain behaviour of haemoglobin?
then apply all the stuff Wilson listed.

Clive

[Tipsy]

I am only just learning chemistry so can't give you any chemistry advice, however, if you google "arterial blood gases" you will find part of the answer to your questions.

I can tell you that the answer to C is "death"  unless you get to the hospital quick


edit: easiest explanation of ABG's
http://www.anzcp.org/CCP/Physiology/Arterial%20Blood%20Gases.htm

hope it helps!