[chmjmhi]

I have found one example in the literature where the authors claim that a non-racemic mixture of R and S isomers of an organic compound (a convolutamydine) can be purified by letting it crystallise in part. The R and S isomers form 1+1 aggregates (racemic), increasing the ee of the major isomer (still in solution).

Reference: Tetrahedron (2006), 62, 12017-12024.

Could anyone please help me find more examples of this phenomenon, and/or point me towards a review on this topic? I have recently experienced some weird chiral HPLC results and I want to try and make certain that I haven't seen the same phenomenon.

[Mitch]

You could try emailing the authors and let us know what they say.

[chmjmhi]

I have actually emailed the authors, but haven't gotten a reply back.

I would still be very interested if anyone in the community has seen anything like this before. When I searched for literature I was somewhat limited in my choice of keywords because it's borderline physical/solid state chemistry and I may not be familiar with the correct terminology, plus English is not my mother language.