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Topic: E1 Elimination and Hydride/Alkyl Shifts  (Read 3461 times)

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Offline nj_bartel

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E1 Elimination and Hydride/Alkyl Shifts
« on: November 25, 2008, 06:48:28 PM »
Do you have to consider hydride/alkyl shifts in E1 eliminations?  Both processes are intramolecular, so not sure =/
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Offline macman104

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Re: E1 Elimination and Hydride/Alkyl Shifts
« Reply #1 on: November 25, 2008, 07:16:35 PM »
As a blanket example, I would say yes.  It depends as well on what structure you get after the shift, how stable, etc.
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Offline nj_bartel

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Re: E1 Elimination and Hydride/Alkyl Shifts
« Reply #2 on: November 25, 2008, 11:03:05 PM »
Apparently E1 isn't intramolecular; you do need some sort of weak base to pull off the proton.  (so yea, you do need to consider potential hydride shifts).  Thanks.
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