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Topic: Knoevenagel Condensation  (Read 3312 times)

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Offline lasset

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Knoevenagel Condensation
« on: April 01, 2009, 03:02:33 AM »
I trying to synthesize ethylcoumarin-3-carboxylate and got to the part shown in the picture. How does the cyclisation occur?

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Offline sjb

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Re: Knoevenagel Condensation
« Reply #1 on: April 01, 2009, 06:47:14 AM »
Can you see any new nucleophiles / electrophiles? It may help if you draw the bond angles a little more realistically - for instance the aryl-olefin C-C bond seems a little askew.
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Offline AWK

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Re: Knoevenagel Condensation
« Reply #2 on: April 01, 2009, 08:50:59 AM »
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