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Topic: Mechlorethamine  (Read 3080 times)

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Offline lutesium

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Mechlorethamine
« on: April 09, 2009, 07:42:59 AM »
How can the N-methyl group be weakened? By bonding more EWG s into the molecule? If the N methyl group is weakened does the N become more electrophilic?

Thanks!!!


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Offline gfunk

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Re: Mechlorethamine
« Reply #1 on: April 09, 2009, 08:04:15 AM »
What do you mean by "weakening" the group?
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Grad Student - Organic Chemistry
University of Alberta

Offline lutesium

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Re: Mechlorethamine
« Reply #2 on: April 10, 2009, 05:40:15 AM »
Weakening the N-CH3 bond. If this bond is weakened would the molecule (N-desmethyl MechlorEthAmine ) accept a -CH3 group easier or harder...
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Offline lutesium

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Re: Mechlorethamine
« Reply #3 on: April 12, 2009, 07:10:18 AM »
Noone has an idea?


Lutesium...
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