As the flow rates increase, there may be back pressures that can affect the mixing. Ideally, you want the gas pressures in the tubes prior to mixing to be near atmospheric. Keeping them at identical pressures above ambient while flowing can be done, but it's not a simple or inexpensive task.
Moreover, their temperatures have to be the same, or ambient. Coming straight from the cylinder, they may be cold if you don't take precautions.
It really depends on choosing the accuracy you need in an informed matter for the application. For instance, you needn't specify 0.1% if you're working with a sensor that's only accurate to 2%.
Rotameters aren't very accurate, either, and require constant tending.
This is the business I'm in. Read this, from my website:
http://www.customsensorsolutions.com/dilution.htmBill Penrose