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Topic: synthesis of 5-(1H-Pyrazol-4-yl)thiophene-2-carboxylic Acid -----Need your help  (Read 2854 times)

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Offline wallysheng

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synthesis of 5-(1H-Pyrazol-4-yl)thiophene-2-carboxylic Acid -----Need your help
« on: November 19, 2009, 10:04:45 AM »
We have a project recently need to synthesize 5-(1H-Pyrazol-4-yl)thiophene-2-carboxylic Acid  for about 10-20grams.
Has anybody done this compound before? Do you have any suggestion or literature for us to refer to?

Thank you!
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Offline sjb

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Re: synthesis of 5-(1H-Pyrazol-4-yl)thiophene-2-carboxylic Acid -----Need your help
« Reply #1 on: November 19, 2009, 05:18:08 PM »
What about Suzukis or similar with 4-halopyrazole and 5-boronic esters of thiophene-2-carboxylic acid?

Seems that aryl bond is fundamental to making this class of molecule.

How did the difluorobicycle work out - I note it's not on your website?
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