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lactam, lactone...
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Topic: lactam, lactone... (Read 3474 times)
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migueldario
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lactam, lactone...
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on:
March 23, 2010, 11:03:52 PM »
hi.. i need to know what the reaction mechanism for the formation of lactams from amino acids, lactones from hydroxyacids, and cyclic anhydrides from diacids
i hope someone can help me
sorry for my english... i am from venezuela..
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lancenti
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Re: lactam, lactone...
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Reply #1 on:
March 24, 2010, 01:56:53 AM »
All of these mechanisms are actually the same as having two separate molecules. So the mechanism of lactam formation is the same as the formation of an amide, lactone formation is the same as the formation of an ester.
It might help if you did these reactions in acidic conditions so that you can make the C=O more electrophilic.
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lactam, lactone...