[OscarMike]

I will come straight first off and say that I am not a chemistry professional - far from it. An O level 25 years ago is it.

However, I am desperate to find out a little more about a specific topic. I have searched Google in every way I can think of and come up with nothing.

Essentially, in my blood there are (was) "chloromandelic acid derivatives". The report goes on to say that these are "metabolites of some organophosphates". I want to find out more about this independently but have drawn a total blank.

Essentially, what has to happen to an organophosphate to make it into a chloromandelic acid derivative?

Many thanks.

[Smrt guy]

The question is too broad to offer an appropriate answer.  Your best bet would be to search for organophosphates that are structurally related and try to learn more about organophosphate bioactivity.  You could start with examining how you came into contact with organophosphates (insecticides, etc).

[OscarMike]

OK, the organophosphate I came into contact with is tricresyl phosphate (TCP). It came from jet engine oil which may well have been heated and contains 3% TCP. I am interested what happens to TCP to create the chloromandelic acid derivatives.

The only research I can find shows that heated TCP can produce trimethylolpropane phosphate (TMPP). A brief synopsis of this is here.

I can find lots of other research on the effects of TCP and TMPP but nothing on my original question.

Don't worry if it is too general to answer but am a bit stuck as to where else to turn!