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Topic: Protecting Group Chemistry  (Read 5834 times)

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Offline kimyacı

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Protecting Group Chemistry
« on: May 05, 2010, 10:44:09 AM »
 Hi all,
while ı am studying protecting group chemistry, ı see (lm)2 CO in the protecting of diols. I dont know what this is.I looked at internet but ı couldnt find.If anyone knows this,please inform me
 Thanks in advance

Offline Doc Oc

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Re: Protecting Group Chemistry
« Reply #1 on: May 05, 2010, 11:01:05 AM »
Carbonyl diimidazole.  Like phosgene but without the nasty effect on your well-being.

Offline AWK

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Offline kimyacı

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Re: Protecting Group Chemistry
« Reply #3 on: May 05, 2010, 12:52:54 PM »
 Thanks a lot dear J-bone

Offline AWK

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Re: Protecting Group Chemistry
« Reply #4 on: May 06, 2010, 12:43:37 AM »
Carbonyl diimidazole.  Like phosgene but without the nasty effect on your well-being.
But reagent is prepared from fosgene by peoples in other place
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Offline pacifyer

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Re: Protecting Group Chemistry
« Reply #5 on: May 12, 2010, 07:03:08 PM »
Carbonyl diimidazole.  Like phosgene but without the nasty effect on your well-being.
But reagent is prepared from fosgene by peoples in other place

Or from safer triphosgene, perhaps...  ;)

Offline OC pro

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Re: Protecting Group Chemistry
« Reply #6 on: May 13, 2010, 06:36:04 AM »
But not on an industrial scale. Just compare the prizes. Triphosgene is not much less toxic than phosgene itself. It is just a bit easier to handle.

Offline pacifyer

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Re: Protecting Group Chemistry
« Reply #7 on: May 13, 2010, 03:50:51 PM »
But not on an industrial scale. Just compare the prizes. Triphosgene is not much less toxic than phosgene itself. It is just a bit easier to handle.

Triphosgene is MUCH less toxic than phosgene, and as long as you do not use it to generate phosgene, you will be ok. Phosgene is a sever irritant, and you must handle it in a hood, and with due respect and love. You should keep it in a tightly closed container and far from water.
I would not buy it, but prepare it, instead, it is not that hard, and as triphosgene is solid, it is pretty easy to handle and convenient to use. I this way I could be sure of the stuff, and its quality and purity... You can always make only what will be needed, and use it as limiting reagent.

I think you should take a look at:
Cotarca, L.; Delogu, P.; Nardelli, A.; Sunjic, V. Synthesis 1996, 553.

Also, for some applications
http://www.sigmaaldrich.com/etc/medialib/docs/Aldrich/Bulletin/al_techbull_al176.Par.0001.File.tmp/al_techbull_al176.pdf

Hope it helps.

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