[muhammed ali]

I WOULD LIKE TO KNOW THAT HOW CAN I REMOVE DMF SOLVENT FROM REACTION MIXTURE.
AND CAN IT BE USED INSTEAD OF DIPHENYL ETHER ?

[Borek]

Please read forum rules.

Don't abuse capital letters.

[OC pro]

YOu can remove DMF on a good rotavapor or more simply via aqueous work-up. Means you add an organic solvent (e.g. ethyl acetate, diethyl ether, dichloromethane, ...) and add water. Most of the DMF will go into the water layer. The combined organic layers will be washed then with water.

[AC Prabakar]

You can remove DMF on a good rotavapor or more simply via aqueous work-up. Means you add an organic solvent (e.g. ethyl acetate, diethyl ether, dichloromethane, ...) and add water. Most of the DMF will go into the water layer. The combined organic layers will be washed then with water.

Yes this is very good method to remove DMF!
Water with toluene will be a good option.
Refer the below paper to know the exact quantity of water in organic phase and vice versa.

Organic Process Research & Development 2007, 11, 160-164 or follow the below link

http://pubs.acs.org/doi/pdf/10.1021/op060154k