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Specifically, the publication with second highest impact factor in the "science" category is Acta Crystallographica - Section A, knocking none other than the New England Journal of Medicine from the runner's up position. This title's impact factor rocketed up to 49.926 this year, more than 20-fold higher than last year. A single article published in a 2008 issue of the journal seems to be responsible for the meteoric rise in the Acta Crystallographica - Section A's impact factor.