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Topic: n-oxide in ether solvent  (Read 3354 times)

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Offline shrikantvarma

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n-oxide in ether solvent
« on: July 21, 2010, 12:38:53 PM »
is it true that n-oxide of amine compound will form in trace amount while using ether solvent?

Offline 408

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Re: n-oxide in ether solvent
« Reply #1 on: July 21, 2010, 04:22:10 PM »
Depends which amine.  I doubt all do or I would not need to use hypofluorous acid to generate some oxides.

Offline discodermolide

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Re: n-oxide in ether solvent
« Reply #2 on: July 21, 2010, 05:53:58 PM »
is it true that n-oxide of amine compound will form in trace amount while using ether solvent?

Depends on how much peroxide is present in the ether solvent.
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Offline shrikantvarma

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Re: n-oxide in ether solvent
« Reply #3 on: July 22, 2010, 11:09:09 AM »
my compound have trace amount of n-oxide which is form while i am doing workup in ether solvent, by doing repeated crystallization the n-oxide not wash out completelly,which is best method to remove n-oxide from organic compound ??

Offline discodermolide

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Re: n-oxide in ether solvent
« Reply #4 on: July 22, 2010, 12:42:53 PM »
try a reductive work-up. or better do not use an etheric solvent
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Offline Smrt guy

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Re: n-oxide in ether solvent
« Reply #5 on: July 31, 2010, 08:47:06 PM »
Use distilled ether and you may not see the oxidation product.

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