[marthaj]

Hi
I'd like to receive help because EDC is a carbodiimide used in water like solvent.
But I dont understand, does EDC decomposes in water or not? if not, how the carbodiimide can remove water ?
Thank you

[dunno260]

EDC forms a urea that is quite water soluble (particullarly when the amine is protonated) that assists removing the urea byproduct from the reaction during workup (EDCI is the hydrochloride salt that can be used).  Dicyclohexylurea from DCC isn't soluble in water and tends to be soluble in quite a few organic solvents and can be somewhat problematic to remove.

Though I am not quite sure if that was what you were asking because it somewhat sounded like you were asking if you could use EDC as a dehydrating agent which I suppose you could, but I imagine you would have to have some base around.

[marthaj]

hi Dunno
Could you help me to know how to remove HOBt and DMAP  in the end of the reaction. I want to know if those compounds stay in the organic phase or aqueous phase.
thank you