I'm not entirely sure what this 2.1 vs 2.2 is, it sounds like it's your grading system (different here in the US).
It's more than possible to get a job without stellar grades, you actually don't even need to list them on your resume. I think the larger problem for you is that the UK got absolutely murdered in the sweeping layoffs that started earlier this year. Many facilities shuttered their doors completely and left the entirety of the staff without jobs. It's not going to be easy for anyone, including you.
One thing you can maybe do is find a lab tech position at a small local university. This could be something as simple as working in the stockroom, or it could entail preparing buffer solutions and other lab work. It might be monotonous or mindless, but it will allow you to get some experience and that will help you move up into a more full-time research position.
Best of luck.