[wonka_vision]

Hello,

I'm interested in isolating a reaction product (small molecule), and I'm unsure about the particular grade of silica gel to be used for flash chromatography. I was going to go with a mesh size around 70-250, but I'm uncertain about the role of pore size and purity. I know the higher purity silica gel tends to be expensive, and I would like to go as cheap as possible without compromising a successful separation. Can anyone give me an idea of a particular brand and grade of silica gel for use in my application?

Thanks

[majorjp]

A silica gel with a mesh size of 70-250 is more often used for gravity chromatography, if you are going to use flash chromatography a mesh size of 230-400 is more practical. We always use Sigma-Aldrich and go with Grade 9385 for flash chromatography is has a pore size of 60A. But the pore size choice is mainly based on your molecule's size and the size of the materials you're trying to isolate it from.