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Abiraterone acetate
CAS:154229-18-2
purity:99%
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Abiraterone Acetate (CB7630)

Abiraterone acetate (CB7630) is an orally administered inhibitor of the steroidal enzyme CYP17 (17α-hydroxylase/C17,20 lyase), a cytochrome p450 complex that is involved in testosterone production and estrogen production.

Scientists believe that testosterone levels in the testes and adrenals stimulate the growth of prostate cancer cells. In preclinical and clinical studies, CB7630 has demonstrated the ability to selectively inhibit the target enzyme, resulting in inhibition of testosterone production in both the adrenals and the testes.

The growth of many breast cancer cells has been shown to be estrogen dependent. Since the steroidal hormones upstream of aromatase and downstream of CYP17 could be important in the activation of estrogen and other nuclear steroid hormone receptors in breast cancer, CB7630 may impact breast cancer cell proliferation and survival by virtue of its estrogen suppressing activity.