[ONUR GÜMÜŞ]

hi, ı want to leaving to methyl group in this structure. ı tried so much. but it didn't be. how can ı leave this group? thanks for your helps.

[discodermolide]

hi, ı want to leaving to methyl group in this structure. ı tried so much. but it didn't be. how can ı leave this group? thanks for your helps.

which methyl groups, those on N or the acetamide methyl?

[ÖZGÜR LAFCI]

 . it is methyl that connected with carbonyl group.

[orgstudy]

You can use iodoform rxn to get

        O
        ll
- N - C -ONa
   l

is this what you are looking for?

[ONUR GÜMÜŞ]

ı am synthesing chalcone. but this methyl is not leaving.

[ONUR GÜMÜŞ]

problem is be deriving from electron couple upon N.

[discodermolide]

ı am synthesing chalcone. but this methyl is not leaving.

I'm still not sure what you want. In the structure you drew convert the amide to an acid, then make the azide and do a Curtius rearrangement, the methyl group should end up on the nitorgen.

[ONUR GÜMÜŞ]

 ok. what is the conditions for iodoform reaxion?.can you write. please.

[orgstudy]

it just needs a group like     O        and base like NaOH or KOH and halogen(X2) ...
                                      ll
                             CH3 - C -

Check this: http://en.wikipedia.org/wiki/Haloform_reaction#Iodoform_test


But even i'm not getting what you want. chalcone ... you want to replace CH3 with phenyl???

[ONUR GÜMÜŞ]

I tried to base but it didn't..bases dosen't work. I didn't pluck a proton in methyl..

[AWK]

Haloform reaction works only for methylketones, but not for amides or esters.
The only way to get desired result is to is to use formyl group instead.

[ONUR GÜMÜŞ]

formyl group also did not work...I think there is no way of pluck the methyl

[Hybrid]

till now i don't understand what are u trying to do, chalcone of what ??
u want the CH3 to  be active or u want  a chalcone on amide C=O