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Topic: Biginelli reaction  (Read 2595 times)

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Offline km

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Biginelli reaction
« on: February 23, 2011, 10:58:56 AM »
when the Biginelli reaction is carried under solvent free conditions using Lewis acids, what does the Lewis acid do exactly?
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Offline AWK

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Re: Biginelli reaction
« Reply #1 on: February 24, 2011, 01:09:16 AM »
Acid is a catalyst in this reaction.
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Offline MissPhosgene

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Re: Biginelli reaction
« Reply #2 on: February 26, 2011, 07:03:50 PM »
Why wouldn't an acid catalyst do some serious damage to the rate of addition of urea to the aldehyde? Wouldn't urea sequester it? Otherwise, it seems like a great facilitator of the reaction.
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