Hi all,
I was looking for input on the best way to lithiate an alkyl halide. The problem is, the alkyl halide has a great LG on one end and the halide on the other, so once the halide is exchanged with lithium, intramolecular reactions can occur as well as polymerization. I've tried Li/X exchange with BuLi, but I am wondering if I could expect less side products and a cleaner reaction if I do a direct lithiation with 2eq Li metal. Any thoughts?
Thanks!