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Topic: Reactions with Benzene  (Read 2355 times)

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Offline Arees

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Reactions with Benzene
« on: October 16, 2011, 12:27:50 AM »
Starting with benzene, I need to obtain 2-nitro-4-chlorophenol using nitration, chlorination, sulfonation and hydroxylation in the correct orders, written question, not a lab procedure.

I've come up with this and I'm just wondering if it's the most efficient way:

1. Chlorination, since chlorine is an ortho-para director
2. sulfonation/hydroxylation to add the OH group in the para position, OH is an ortho-para director
3. nitration, adding the NO2 group in the ortho position

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