[taolihunt1133]

Hello Peers,

What is the most effective and efficient way if synthesizing aspirin. I know there are two methods using salicylic acid, acetic anhydride and ketene. But there is also another method where you use the previous compounds but replace ketene with phosphoric acid. If anyone know of a better way or of the two I specified can you please let me know.


Thank you

[AWK]

but replace ketene with phosphoric acid

wrong statement!
Phosphoric acid sometimes is used instead of sulphuric acid as catalyst in synthesis with acetic anhydride.

[taolihunt1133]

So you do need ketene either way? And are you suggesting that sulfuric acid can be used instead of phosphoric as just a catalyst in the reaction and if true how much concentration percentage does sulfuric acid need to be since phosphoric was 85%?