Dear all,
I am doing a synthesis of methacryloyl chloride with 1-amino-2-propanol, I feed 1.5 equivalent of methacryloyl chloride with 1 equivalent of 1-amino-2-propanol. After the reaction, I got almost full conversion of 1-amino-2-propanol and around 0.5 equivalent methacryloyl chloride. Then I am thinking how to remove the unreacted methacryloyl chloride. Do you guys think it is possible to purify it by passing the crude product through an aluminum oxide column as methacryloyl chloride is pretty polar? Or I can wash the crude product with NaOH and convert the unreacted methacryloyl chloride to methacrylic acid and then pass the crude product through an aluminum oxide column.
Please let me know what you think about the purification? All your ideas are appreciated.
Thanks for your time.
Regards,
John